abstract：PURPOSE:Levodopa and dopamine (DA) agonist therapy are two common treatments for Parkinson's disease (PD). There is controversy about the effects of these treatments on disease progression and imaging markers. Here we used multi-tracer positron emission tomography imaging and a unilateral 6-hydroxydopamine (6-OHDA) rat...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sossi V,Dinelle K,Schulzer M,Mak E,Doudet DJ,de la Fuente-Fernández R

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a myocardial disease that predominantly affects the right ventricle (RV). Its hallmark feature is fibro-fatty replacement of RV myocardium. However, patchy inflammatory infiltrates in the RV are also consistently reported using autopsy and my...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Campian ME,Verberne HJ,Hardziyenka M,de Groot EA,van Moerkerken AF,van Eck-Smit BL,Tan HL

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:Improved bifunctional chelates (BFCs) are needed to facilitate efficient (64)Cu radiolabeling of monoclonal antibodies (mAbs) under mild conditions and to yield stable, target-specific agents. The utility of two novel BFCs, 1-Oxa-4,7,10-triazacyclododecane-5-S-(4-isothiocyanatobenzyl)-4,7,10-triacetic acid (p-S...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ferreira CL,Yapp DT,Crisp S,Sutherland BW,Ng SS,Gleave M,Bensimon C,Jurek P,Kiefer GE

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:To contribute to the differentiation of Parkinson's disease (PD) and essential tremor (ET), we compared two different artificial neural network classifiers using (123)I-FP-CIT SPECT data, a probabilistic neural network (PNN) and a classification tree (ClT). METHODS:(123)I-FP-CIT brain SPECT with semiquantitati...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Palumbo B,Fravolini ML,Nuvoli S,Spanu A,Paulus KS,Schillaci O,Madeddu G

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:In a minority of cases a definite diagnosis and stage grouping in cancer patients is not possible based on the imaging information of PET/CT. We report our experience with percutaneous PET/CT-guided bone biopsies to histologically verify the aetiology of hypermetabolic bone lesions. METHODS:We retrospectively ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Klaeser B,Wiskirchen J,Wartenberg J,Weitzel T,Schmid RA,Mueller MD,Krause T

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:To determine if PET reporting criteria for the Response Adapted Treatment in Hodgkin Lymphoma (RATHL) trial could enable satisfactory agreement to be reached between 'core' laboratories operating in different countries. METHODS:Four centres reported scans from 50 patients with stage II-IV HL, acquired before a...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Barrington SF,Qian W,Somer EJ,Franceschetto A,Bagni B,Brun E,Almquist H,Loft A,Højgaard L,Federico M,Gallamini A,Smith P,Johnson P,Radford J,O'Doherty MJ

更新日期：2010-10-01 00:00:00

abstract：:This proposal for standardization of (123)I-metaiodobenzylguanidine (iobenguane, MIBG) cardiac sympathetic imaging includes recommendations for patient information and preparation, radiopharmaceutical, injected activities and dosimetry, image acquisition, quality control, reconstruction methods, attenuation, scatter a...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Flotats A,Carrió I,Agostini D,Le Guludec D,Marcassa C,Schäfers M,Somsen GA,Unlu M,Verberne HJ,EANM Cardiovascular Committee.,European Council of Nuclear Cardiology.

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:Although [(18)F]FDG PET can measure therapy response sooner and more accurately than morphological imaging techniques, there is still some debate as to whether [(18)F]FDG uptake really reflects changes in the viable cell fraction. In this study changes in [(18)F]FDG uptake were investigated in a lymphoma model ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Brepoels L,De Saint-Hubert M,Stroobants S,Verhoef G,Balzarini J,Mortelmans L,Mottaghy FM

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:Prostate stem cell antigen (PSCA), a cell surface glycoprotein expressed in normal human prostate and bladder, is over-expressed in the majority of localized prostate cancer and most bone metastases. We have previously shown that the hu1G8 minibody, a humanized anti-PSCA antibody fragment (single-chain Fv-C(H)3...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Lepin EJ,Leyton JV,Zhou Y,Olafsen T,Salazar FB,McCabe KE,Hahm S,Marks JD,Reiter RE,Wu AM

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:To determine if preoperative [(18)F]FDG-PET/CT imaging has prognostic significance in patients with uterine cervical cancer. METHODS:Patients with FIGO stage IB to IIA cervical cancer were imaged with integrated FDG PET/CT before radical surgery. The relationship between the maximum standardized uptake value (...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Chung HH,Nam BH,Kim JW,Kang KW,Park NH,Song YS,Chung JK,Kang SB

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:Low-grade joint infections are characterized by infiltration of granulocytes, which mediate aspects of inflammatory changes. We evaluated retrospectively the contribution of SPECT/CT as an addition to planar scintigraphy with (99m)Tc-labelled antigranulocyte antibodies for diagnosing and localizing low-grade jo...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Graute V,Feist M,Lehner S,Haug A,Müller PE,Bartenstein P,Hacker M

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:The purpose of this prospective study was to evaluate the usefulness of (18)F-fluorodeoxyglucose (FDG) and (11)C-choline positron emission tomography (PET)/computed tomography (CT) for detecting recurrences of advanced head and neck cancer after combined intra-arterial chemotherapy and radiotherapy. Additionall...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ito K,Yokoyama J,Kubota K,Morooka M,Shiibashi M,Matsuda H

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the accuracy of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT to visualize lymph node metastases before the start of neoadjuvant chemotherapy and to determine how often the visualization is sufficiently prominent to allow monitoring of the axillary resp...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Straver ME,Aukema TS,Olmos RA,Rutgers EJ,Gilhuijs KG,Schot ME,Vogel WV,Peeters MJ

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:Overactivity of the multidrug efflux transporter P-glycoprotein (P-gp) at the blood-brain barrier (BBB) is believed to play an important role in resistance to central nervous system drug treatment. (R)-[(11)C]verapamil (VPM) PET can be used to measure the function of P-gp at the BBB, but low brain uptake of VPM...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kuntner C,Bankstahl JP,Bankstahl M,Stanek J,Wanek T,Stundner G,Karch R,Brauner R,Meier M,Ding X,Müller M,Löscher W,Langer O

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:Monoclonal anti-CD33 antibodies conjugated with toxic calicheamicin derivative (gemtuzumab ozogamicin, GO) are a novel therapy option for acute myeloid leukaemia (AML). Key prognostic factors for patients with AML are high CD33 expression on the leukaemic cells and the ability to overcome mechanisms of resistan...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Petrich T,Korkmaz Z,Krull D,Frömke C,Meyer GJ,Knapp WH

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:The aims were to determine if the maximum standardized uptake value (SUV(max)) of the primary tumor as determined by preoperative (18)F-fluoro-2-deoxyglucose ((18)F-FDG) positron emission tomography (PET) is an independent predictor of overall survival and to assess its prognostic value after stratification acc...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Agarwal M,Brahmanday G,Bajaj SK,Ravikrishnan KP,Wong CY

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:The serotonin-1A (5-HT(1A)) receptor is implicated in the pathophysiology of major neuropsychiatric disorders. Thus, the functional imaging of 5-HT(1A) receptors by positron emission tomography (PET) may contribute to the understanding of its role in those pathologies and their therapeutics. These receptors exi...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Lemoine L,Verdurand M,Vacher B,Blanc E,Le Bars D,Newman-Tancredi A,Zimmer L

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:To determine clinical predictors and accuracy of (123)I-FP-CIT SPECT imaging in the differentiation of drug-induced parkinsonism (DIP) and Parkinson's disease (PD). METHODS:Several clinical features and (123)I-FP-CIT SPECT images in 32 patients with DIP, 25 patients with PD unmasked by antidopaminergic drugs (...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Diaz-Corrales FJ,Sanz-Viedma S,Garcia-Solis D,Escobar-Delgado T,Mir P

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:To elucidate the prognostic role of post-therapeutic (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET), we conducted a retrospective cohort study analysing the clinical factors that affect overall survival after non-operative therapy for unresectable hepatocellular carcinoma (HCC). METHOD...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Higashi T,Hatano E,Ikai I,Nishii R,Nakamoto Y,Ishizu K,Suga T,Kawashima H,Togashi K,Seo S,Kitamura K,Takada Y,Uemoto S

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:4-[(18)F]-ADAM is a potent serotonin transport imaging agent. We studied its toxicity in rats and radiation dosimetry in monkeys before human studies are undertaken. METHODS:Single and multiple-dosage toxicity studies were conducted in Sprague-Dawley rats. Male and female rats were injected intravenously with ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Huang YY,Ma KH,Tseng TW,Chou TK,Ng H,Mirsalis JC,Fu YK,Chu TC,Huang WS,Shiue CY

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:We compared left ventricular (LV) ejection fraction obtained by gated SPECT with that obtained by equilibrium radionuclide angiocardiography in a large cohort of patients. METHODS:Within 1 week, 514 subjects with suspected or known coronary artery disease underwent same-day stress-rest (99m)Tc-sestamibi gated ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Acampa W,Caprio MG,Nicolai E,Liuzzi R,De Luca S,Capasso E,Luongo L,Petretta M,Cuocolo A

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:We investigated the relationship between three-dimensional volumetric data of the metabolically active tumour volume assessed using [(11)C]-methionine positron emission tomography (MET-PET) and the area of gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) enhancement assessed using magnetic resonance imag...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Galldiks N,Ullrich R,Schroeter M,Fink GR,Jacobs AH,Kracht LW

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the predictive potential of pre-operative regional cerebral blood flow (rCBF) in the pre-supplementary motor area (pre-SMA) and clinical factors in Parkinson's disease (PD) patients treated with subthalamic nucleus (STN) stimulation. METHODS:Ten patients underwent rCBF ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sestini S,Pupi A,Ammannati F,Ramat S,Sorbi S,Sciagrà R,Mansi L,Castagnoli A

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:Diabetic patients have a high risk for cardiovascular events. The role of myocardial perfusion imaging was investigated in asymptomatic diabetic patients to evaluate short-term prognosis in a Japanese population. METHODS:A total of 506 asymptomatic patients ≥ 50 years of age who had carotid artery maximum inti...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Nakajima K,Yamasaki Y,Kusuoka H,Izumi T,Kashiwagi A,Kawamori R,Shimamoto K,Yamada N,Nishimura T

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:Despite modern CT systems and expert evaluators, the diagnostic performance of coronary CT angiography is limited by overestimation of vessel stenosis which reduces the positive predictive value (PPV) of the test. The aim of this study was to evaluate the performance of combined cardiac PET/64-detector CT angio...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Groves AM,Speechly-Dick ME,Kayani I,Pugliese F,Endozo R,McEwan J,Menezes LJ,Habib SB,Prvulovich E,Ell PJ

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:Trastuzumab (Herceptin™) is often internalized following binding to Her2+ tumor cells. The objective of this study was to investigate whether trastuzumab can be used as a specific carrier to deliver antisense oligomers into Her2+ tumor cells both in vitro and in vivo. METHODS:A biotinylated MORF oligomer antis...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Wang Y,Liu X,Chen L,Cheng D,Rusckowski M,Hnatowich DJ

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:Although two norepinephrine transporter (NET) radioligands, (S,S)-[(18)F]FMeNER-D(2) and (S,S)-[(11)C]MeNER, have been reported to have different characteristics, there has not been a direct comparative study in vivo. METHODS:In this preliminary study, two rhesus monkeys underwent three PET measurements each, ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Takano A,Gulyás B,Varrone A,Halldin C

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:To assess the radiation dosimetry and biodistribution of (99m)Tc-labeled ethylene dicysteine deoxyglucose ((99m)Tc-EC-DG) in patients with non-small-cell lung cancer (NSCLC). METHODS:Serial whole-body scans were acquired 0, 2, 4, 6 and 24 h after injection of (99m)Tc-EC-DG (925 MBq) in seven NSCLC patients. Ra...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Schechter NR,Erwin WD,Yang DJ,Kim EE,Munden RF,Forster K,Taing LC,Cox JD,Macapinlac HA,Podoloff DA

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:Carimas (Cardiac Image Analysis System) is a new software package developed at the Turku PET Centre for the quantitation of PET studies of the heart with a broad range of tracers. The goal of this study was to assess the reproducibility of results the package provides for myocardial perfusion (MP) quantitation ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Nesterov SV,Han C,Mäki M,Kajander S,Naum AG,Helenius H,Lisinen I,Ukkonen H,Pietilä M,Joutsiniemi E,Knuuti J

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:To evaluate the relationship between coronary artery calcium (CAC) and coronary vasodilator function. METHODS:We evaluated 136 patients without known coronary artery disease (CAD) undergoing vasodilator stress (82)Rb PET/CT and CAC scoring who showed normal myocardial perfusion. The CAC score, resting and hype...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Curillova Z,Yaman BF,Dorbala S,Kwong RY,Sitek A,El Fakhri G,Anagnostopoulos C,Di Carli MF

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:The aims of this study were (1) to evaluate FDG PET/CT and CT for the detection of axillary lymph node metastases in breast cancer (BC) patients and (2) to evaluate FDG PET/CT as a pre-test for the triage to sentinel lymph node biopsy (SLNB) versus axillary lymph node dissection (ALND). METHODS:The sensitivity...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Heusner TA,Kuemmel S,Hahn S,Koeninger A,Otterbach F,Hamami ME,Kimmig KR,Forsting M,Bockisch A,Antoch G,Stahl A

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:The study serves to optimise conditions for multi-pinhole SPECT small animal imaging of (123)I- and (99m)Tc-labelled radiopharmaceuticals with different distributions in murine heart and brain and to investigate detection and dose range thresholds for verification of differences in tracer uptake. METHODS:A Tri...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Pissarek M,Meyer-Kirchrath J,Hohlfeld T,Vollmar S,Oros-Peusquens AM,Flögel U,Jacoby C,Krügel U,Schramm N

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:The J-ACCESS [Japanese investigation of prognosis based on gated single photon emission computed tomography (SPECT)] study found that quantitative gated myocardial SPECT (QGS) is valuable for predicting the prognosis of Japanese patients with known or suspected ischaemic heart disease. The present study evaluat...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Momose M,Nakajima K,Nishimura T

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:Angiotensin-converting enzyme (ACE) and soluble interleukin-2 receptor (sIL-2R) are serological markers, widely used for determining sarcoidosis activity. (18)F-FDG PET has proven to be a sensitive technique in the imaging of sarcoidosis. The aim of this study was to determine sensitivity of (18)F-FDG PET, geno...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Keijsers RG,Verzijlbergen FJ,Oyen WJ,van den Bosch JM,Ruven HJ,van Velzen-Blad H,Grutters JC

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:Cortical atrophy is correlated with the progression of neuropathological lesions within the medial temporal lobes (MTL) in Alzheimer's disease (AD). Our aim was to determine which local and remote functional changes result from MTL volume loss at the predementia stage. METHODS:We studied the relationship betwe...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Guedj E,Barbeau EJ,Didic M,Felician O,de Laforte C,Ranjeva JP,Poncet M,Cozzone PJ,Mundler O,Ceccaldi M

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:Brain imaging of FDG uptake and cerebrospinal fluid (CSF) concentration of amyloid-beta 1-42 (Abeta(1-42)) or tau proteins are promising biomarkers in the diagnosis of Alzheimer's disease (AD). There is still uncertainty regarding any association between decreased FDG uptake and alterations in CSF markers. MET...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Arlt S,Brassen S,Jahn H,Wilke F,Eichenlaub M,Apostolova I,Wenzel F,Thiele F,Young S,Buchert R

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:To investigate clinical implications of FDG uptake in the thyroid glands in patients with advanced breast carcinoma by comparing metabolic and morphologic patterns on positron emission tomography (PET)/computed tomography (CT). METHODS:The institutional review board waived the requirement for informed consent....

journal_title：European journal of nuclear medicine and molecular imaging

authors： Tateishi U,Gamez C,Dawood S,Yeung HW,Cristofanilli M,Inoue T,Macapinlac HA

更新日期：2009-06-01 00:00:00

abstract：INTRODUCTION:Vascular prosthesis infection (VPI) is a life-threatening complication that occurs in 0.5-5% of prostheses. Low-grade infections in non-acute patients are a diagnostic challenge requiring a new method with good diagnostic accuracy. The aim of this work was to define the accuracy of (18)F-FDG PET/CT in thes...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Spacek M,Belohlavek O,Votrubova J,Sebesta P,Stadler P

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:To investigate dynamic ictal perfusion changes during temporal lobe epilepsy (TLE). METHODS:We investigated 37 patients with TLE by ictal and interictal SPECT. All ictal injections were performed within 60 s of seizure onset. Statistical parametric mapping was used to analyse brain perfusion changes and tempor...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Dupont P,Zaknun JJ,Maes A,Tepmongkol S,Vasquez S,Bal CS,Van Paesschen W,Carpintiero S,Locharernkul C,Dondi M

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:To develop a computer-assisted automated diagnostic system to distinguish among Alzheimer disease (AD), dementia with Lewy bodies (DLB), and other degenerative disorders in patients with mild dementia. METHODS:Single photon emission computed tomography (SPECT) images with injection of N-Isopropyl-p-[(123)I]iod...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ishii K,Kanda T,Uemura T,Miyamoto N,Yoshikawa T,Shimada K,Ohkawa S,Minoshima S

更新日期：2009-05-01 00:00:00